Humans are perhaps the only species with the ability to adapt biologically and culturally to build resilience and survive. Adaptation helps us to live in different climates and habitats and facilitates mutually beneficial interactions with members of our societies. Moreover, resilience is identified as a trait that reflects our ability to conquer challenges. Over time, humans developed many strategies in response to various biological, environmental and manmade obstacles and events. The field of Anthropology provides an understanding of various strategies used by humans to adapt to different stimuli, and the ability to survive traumas and master struggles. These studies are equally essential when we study specific groups or individuals and how they invent diverse ways to survive and thrive. Understanding the impact of various strategies employed by humans to show how they adapt culturally, bioculturally and biologically helps scientists to develop research approaches that are more likely to be successful. I will focus on the effect of adaptations on humans and understanding the difference between adaptation and resilience. Moreover, I will discuss the importance of studying human adaptations from a holistic perspective.